You need to exclude several folders and files shares (if you are using the networked edition) from Eset realtime scanning. Full list to exclude is as follows (not all will be needed):

C:\Documents and Settings\All Users\Application Data\*.*
C:\Program Files\Common Files\Sage Line50\*.*
C:\Program Files\Common Files\Sage SBD\*.*
C:\Program Files\Common Files\Sage Shared\*.*
C:\Program Files\Sage\*.*
\\"SageShare"\Accounts\ACCDATA\*.*
C:\Windows\Line50
S:\